H.R.4833: To require the Secretary of the Treasury to mint coins in commemoration of the quadricentennial of the City of Santa Fe, New Mexico.

Santa Fe Quadricentennial Commemorative Coin Act - Instructs the Secretary of the Treasury, in commemoration of the quadricentennial of the City of Santa Fe, New Mexico, to issue $5 gold coins and $1 silver coins emblematic of the settlement of Santa Fe, New Mexico, the oldest capital city in the United States.

Permits issuance of such coins only during calendar 2010.

Requires the Secretary to pay 50% of surcharges received from such coin sales to: (1) the Santa Fe 400th Anniversary Committee, Inc.; and (2) the Secretary of the Interior to sustain the ongoing mission of preserving Santa Fe, including educational programs, infrastructure and archaeological research activities, and other programs to support the quadricentennial of the establishment of Santa Fe.